The Venereal Disease Research Laboratory test is referred to by the initials VDRL. It is an illustration of a Slide flocculation test used for syphilis serological diagnosis. This test uses cardiolipin antigen as a reagent to find auto-antibody in patient serum. A lecithin and cholesterol- and alcohol-fortified extract of the bovine heart muscle is called cardiolipin antigen. Within two to three weeks of treponemal infection, autoantibodies against cardiolipin are generated as a result of tissue damage. The antigen that promotes the production of autoantibodies is the mitochondrial membrane. Cardiolipin can cause a reaction with certain autoantibodies.
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